AgForce Enables Antigen-conditioned Generative Antibody Design

In three linesAgForce, an encoder-decoder architecture with GNN, addresses three failure modes in antibody design: antigen blindness, vocabulary collapse, and inability to generate antigen-specific sequences. Uses framework dropout, gated bottlenecks, hyperbolic attention, and Mixture Density Network. Improves amino acid recovery by 8% on CHIMERA-Bench.

Summary generated by Claude — human-verified