ConTact: Contact-First Antibody CDR Design via Explicit Interface Reasoning

In three linesConTact explicitly decomposes antibody CDR design into three stages: surface complementarity fingerprints, CDR-antigen contact prediction, and contact-gated feature injection. On CHIMERA-Bench, the model achieves 7% RMSD improvement, 10% F1 gain in epitope awareness, and 0.38 AAR sequence recovery over baselines.

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