Frontier LLM-based agents can overcome the ontology curation bottleneck for natural phenotypes

In three linesLLM agents (Claude and GPT) automatically annotate biological phenotypes by linking free-text descriptions to ontology terms. Tested on Dahrul et al. (2018) Gold Standard benchmark, all agents fall within inter-curator human variability, substantially outperforming the Semantic CharaParser NLP tool on all four metrics.

Summary generated by Claude — human-verified